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Short‐term augmented calcium intake has no effect on sodium homeostasis
Author(s) -
Luft Friedrich C,
Aronoff George R,
Sloan Rebecca S,
Fineberg Naomi S,
Weinberger Myron H
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.64
Subject(s) - endocrinology , medicine , blood pressure , calcium , renin–angiotensin system , aldosterone , plasma renin activity , homeostasis , chemistry , sodium , urinary calcium , norepinephrine , excretion , organic chemistry , dopamine
To test the hypothesis that the supplementation of dietary calcium intake influences sodium homeostasis, the renin‐angiotensin system, and sympathetic nervous system in a manner that might evoke a decrease in arterial blood pressure, we gave 16 participants (eight normal and eight with hypertension) placebo for 8 days, followed by 500 mg elemental calcium as the carbonate salt twice a day for 8 days. The same diet was prepared for each meal for the entire study. Sodium intake was fixed for each participant and averaged 150 mEq/day. All urine was collected every day. Blood was drawn at the end of the placebo and calcium periods for determinations of plasma renin, aldosterone, and norepinephrine values. Calcium supplementation increased urinary calcium excretion significantly in both groups. However, calcium supplementation failed to influence sodium or potassium excretion, serum electrolytes, total serum calcium, renin, aldosterone, or norepinephrine levels, or heart rate. Systolic and diastolic blood pressures were not influenced in normal subjects, but in patients with hypertension the supine systolic blood pressure decreased significantly. We conclude that blood pressure lowering effects of calcium, should they occur, are not likely the result of augmented urinary sodium excretion or of straight‐forward influences on the renin‐angiotensin system or sympathetic nervous system. Clinical Pharmacology and Therapeutics (1986) 39, 414–419; doi: 10.1038/clpt.1986.64