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Dihydroergotamine and mobilization after major orthopedic surgery
Author(s) -
Duus Benn R,
Hølmich Per,
Larsen Carsten T,
WilleJørgensen Peer,
BjergNielsen Arne,
Christensen Steen
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.50
Subject(s) - dihydroergotamine , orthostatic vital signs , medicine , placebo , mobilization , total hip arthroplasty , orthopedic surgery , anesthesia , surgery , blood pressure , archaeology , alternative medicine , pathology , migraine , history
The effects of dihydroergotamine (DHE) on the degree of mobilization and response to orthostatic stress after total hip arthroplasty were studied. In the mobilization study, 78 patients received DHE, 0.5 mg im, twice a day from the day of surgery until full mobilization was achieved. Eighty‐four patients who received placebo served as controls. There was no significant difference in the time until the first day of mobilization or the degree of mobilization. In the orthostatic test condition, subgroups of 61 patients receiving placebo and 55 patients receiving DHE were subjected to orthostatic testing. There were no differences in cardiovascular response to bed rest or in orthostatic stress. We conclude that DHE does not stabilize the cardiovascular reaction to orthostatic stress, nor does it enhance mobilization in patients after total hip arthroplasty. Clinical Pharmacology and Therapeutics (1986) 39, 342–344; doi: 10.1038/clpt.1986.50