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The effect of single intravenous doses of cimetidine or ranitidine on gastric secretion
Author(s) -
Frank William O,
Peace Karl E,
Watson Martha,
Seaman John J,
Szego Peter L,
Braverman Alan,
Mico Bruce,
Dickson Brian
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.242
Subject(s) - cimetidine , ranitidine , gastric acid , medicine , crossover study , histamine h2 receptor , volume of distribution , dosing , stomach , gastric secretion , gastroenterology , anesthesia , pharmacology , antagonist , pharmacokinetics , receptor , placebo , alternative medicine , pathology
Intravenous Cimetidine, 300 mg or 400 mg, or ranitidine, 50 mg, was administered as a single dose to 36 volunteers in a randomized, crossover fashion. Aspirates of gastric juice were obtained after dosing, and the pH, titratable acidity, gastric fluid volume, and gastric acid output were determined from baseline through 7½ hours for each subject. Each intervention significantly increased pH and suppressed hydrogen ion concentration, gastric fluid volume, and gastric acid output. Both the magnitudes of the changes when compared with baseline and the time of the mean maximum effects were similar in all three drug regimens. The effect of all three interventions on gastric fluid volume and gastric acid output diminished sharply after 6 hours. The data indicate that the gastric secretory response to all three interventions did not differ substantially. Clinical Pharmacology and Therapeutics (1986) 40 , 665–672; doi: 10.1038/clpt.1986.242