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Effect of cirrhosis and debrisoquin phenotype on the disposition and effects of pinacidil
Author(s) -
Shaheen Omar,
Patel Jagdish,
Avant George R,
Hamilton M,
Wood Alastair J J
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.240
Subject(s) - pinacidil , cirrhosis , pharmacology , metabolite , medicine , endocrinology , glibenclamide , diabetes mellitus
Pinacidil is an investigational vasodilator currently undergoing clinical trials as an antihypertensive agent. It is metabolized in humans to pinacidil N ‐oxide. To determine whether pinacidil's metabolism or effects were influenced by either liver disease or the subject's debrisoquin phenotype, eight patients with chronic stable cirrhosis and 13 healthy subjects were studied. Seven of the healthy volunteers were extensive metabolizers of debrisoquin, whereas six were of the poor metabolizer phenotype. Neither the clearance of pinacidil nor the production of the N ‐oxide was altered by the subjects' debrisoquin phenotype. Cirrhosis produced a 50% reduction in pinacidil's clearance (20.7 ± 1.4 vs. 42.1 ± 5.1 L/hr; P < 0.0005) and a prolongation in the elimination t ½ from 3.9 ± 0.3 to 6.1 ± 0.6 hours (P < 0.01). Less pinacidil was metabolized to the N ‐oxide metabolite in the patients with cirrhosis than in the normal individuals. Thus pinacidil's metabolism and clearance are reduced in patients with cirrhosis but are independent of debrisoquin phenotype. Clinical Pharmacology and Therapeutics (1986) 40 , 650–655; doi: 10.1038/clpt.1986.240