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Exercise during therapeutic beta‐blockade: A two‐year study in hypertensive patients
Author(s) -
FriskHolmberg M,
Ström G
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.196
Subject(s) - betaxolol , medicine , heart rate , blood pressure , placebo , blockade , tachycardia , clinical pharmacology , diastole , anesthesia , cardiology , pharmacology , surgery , timolol , alternative medicine , intraocular pressure , receptor , pathology
The use of ß‐adrenoceptor blocking drugs has been thought to impair physical performance. To test this statement, 12 patients with mild to moderate hypertension performed a submaximal exercise test during treatment with placebo and after 3 and 24 months of monotherapy with betaxolol, 20 to 40 mg daily. The resting heart rate and systolic and diastolic blood pressures were reduced after 3 months of treatment and the reduction was maintained 24 hours after the last dose at the 2‐year visit. A 12% to 14% reduction of exercise‐induced tachycardia was found, but blood pressure during exercise was reduced only in the patients with mild hypertension. However, in no patient did the working capacity decrease. Clinical Pharmacology and Therapeutics (1986) 40, 395–399; doi: 10.1038/clpt.1986.196