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Theophylline pharmacokinetics in pregnancy
Author(s) -
Frederiksen Marilynn C,
Ruo Tsuen Ih,
Chow May J,
Atkinson Arthur J
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.183
Subject(s) - theophylline , pharmacokinetics , pregnancy , medicine , volume of distribution , metabolic clearance rate , postpartum period , third trimester , clinical pharmacology , gestation , pharmacology , endocrinology , genetics , biology
Theophylline pharmacokinetics were studied serially in five women during and after pregnancy. Theophylline protein binding was reduced to 11.1% ± 4.7% (P < 0.01) and 13.0% ± 5.9% (P < 0.01) during the second and third trimesters of pregnancy, respectively, compared with 28.1% ± 2.8% when the patients were more than 6 months postpartum. Similar comparisons indicate that theophylline distribution volume and elimination t 1/2 were increased from 30.7 ± 4.4 L and 262 ±57 minutes to 36.8 ± 4.2 L (P < 0.05) and 389 ± 73 minutes (P < 0.01) in the third trimester of pregnancy. In the second and third trimesters, intrinsic nonrenal clearance was reduced to 0.82 ± 0.25 ml/min · kg (P < 0.05) and 0.67 ± 0.18 ml/min • kg (P < 0.01) compared with a remote postpartum value of 1.25 ± 0.37 ml/min · kg. However, these reductions were offset by increases in theophylline intrinsic renal clearance so that apparent reductions in the overall unbound clearance of this drug did not reach statistical significance either during pregnancy or in the early postpartum period. Clinical Pharmacology and Therapeutics (1986) 40, 321–328; doi: 10.1038/clpt.1986.183