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Arterial isoflurane concentration and EEG burst suppression during cardiopulmonary bypass
Author(s) -
Loomis Christopher W,
Brunet Donald,
Milne Brian,
Cervenko Frank W,
Johnson Graeme D
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.181
Subject(s) - isoflurane , burst suppression , anesthesia , medicine , cardiopulmonary bypass , hypothermia , arterial blood , propofol , electroencephalography , psychiatry
Isoflurane (1.5 to 3.0 vol% in oxygen) was used to control intraoperative hypertension in 10 patients undergoing hypothermic cardiopulmonary bypass surgery. Isoflurane was administered through the membrane oxygenator of the bypass pump and yielded plateau concentrations in arterial blood ranging from 36.6 to 84.4 μg/ml (0.5 and 1.16 vol%, respectively). Isoflurane dosing resulted in prolonged periods (21 to 63 minutes) of EEG burst suppression and isoelectric activity in nine patients. Burst suppression was not a result of hypothermia. There was a close temporal relationship between isoflurane concentration and the onset of burst suppression (mean onset time: 27.3 ± 4.56 minutes after isoflurane was begun). The mean arterial isoflurane concentration at the onset of burst suppression was 46.5 ± 10.7 μg/ml; the nasopharyngeal temperature was 26.0° ± 0.61° C Isoflurane was eliminated rapidly from blood with a mean apparent t 1/2 of 18.8 ± 5.46 minutes. Clinical Pharmacology and Therapeutics (1986) 40, 304–313; doi: 10.1038/clpt.1986.181