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Tolerance and pilot pharmacokinetics of amiflamine after increasing single oral doses in healthy subjects
Author(s) -
Alván G,
Graffner C,
Grind M,
Gustafsson L L,
Lindgren J E,
Nordin C,
Ross S,
Selander H,
Siwers B
Publication year - 1986
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1986.142
Subject(s) - clinical pharmacology , pharmacokinetics , pharmacology , urine , biotransformation , oral administration , medicine , monoamine oxidase inhibitor , plasma concentration , monoamine oxidase , chemistry , biochemistry , enzyme
Oral doses of 1 to 100 mg amiflamine, a new reversible monoamine oxidase type A—selective inhibitor, were given for the first time in humans to six healthy men. No apparent pharmacologic effects were recorded until the 80 mg dose. After 100 mg, one subject developed symptoms indicative of an overdose. Amiflamine is extensively metabolized by two consecutive N ‐demethylations. The biotransformation patterns in plasma and urine were found to correlate with the debrisoquin metabolic ratio. Clinical Pharmacology and Therapeutics (1986) 40, 81–85; doi: 10.1038/clpt.1986.142