Premium
Triazolam and ethanol interaction: Kinetic and dynamic consequences
Author(s) -
Dorian Paul,
Sellers Edward M,
Kaplan Howard L,
Hamilton Carolyn,
Greenblatt David J,
Abernethy Darrell
Publication year - 1985
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1985.88
Subject(s) - triazolam , psychomotor learning , ethanol , placebo , chemistry , pharmacology , anesthesia , clinical pharmacology , psychology , medicine , biochemistry , benzodiazepine , psychiatry , cognition , receptor , alternative medicine , pathology
The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/ L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC 0‐∞ . increased (X̄ ± SD = 21% ± 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand‐eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes. Clinical Pharmacology and Therapeutics (1985) 37, 558–562; doi: 10.1038/clpt.1985.88