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Reduction of serum theophylline levels by terbutaline in children with asthma
Author(s) -
Danziger Yardena,
Garty Moshe,
Volwitz Benjamin,
Ilfeld David,
Varsano Itzhak,
Rosenfeld Joseph B
Publication year - 1985
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1985.73
Subject(s) - theophylline , terbutaline , crossover study , bronchodilator , asthma , placebo , medicine , serum concentration , clinical pharmacology , anesthesia , pharmacology , chemistry , alternative medicine , pathology
We studied the effect of oral terbutaline on serum theophylline levels in 12 children with asthma. Sustained‐release theophylline (10 mg/kg twice a day) was given with placebo or terbutaline (0.075 mg/ kg three times a day) in a chronic, randomized, double‐blind, crossover design. The trough serum theophylline concentration fell from 13.8 ± 4.0 to 10.8 ± 3.6 μg/ml and the peak expiratory flow rate increased from 285 ± 30 to 310 ± 29 L/min after terbutaline. Further investigation is needed to clarify the mechanism of action by which terbutaline decreases serum theophylline levels. Clinical Pharmacology and Therapeutics (1985) 37, 469–471; doi: 10.1038/clpt.1985.73