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Effect of alprazolam on digoxin kinetics and creatinine clearance
Author(s) -
Ochs Hermann R,
Greenblatt David J,
VerburgOchs Birgitt
Publication year - 1985
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1985.230
Subject(s) - alprazolam , digoxin , creatinine , renal function , pharmacology , medicine , chemistry , heart failure , psychiatry , anxiety
Eight healthy men received a single, 1.25 mg dose of digoxin on two occasions, once in an otherwise drug‐free control state and again while concurrently receiving alprazolam, 1.5 mg/day. There was no significant difference between control and alprazolam conditions in digoxin volume of distribution (11.0 vs. 11.2 L/kg), elimination t ½ (46 vs. 41 hours), or total clearance from serum (2.8 vs. 3.6 ml/min/kg). Alprazolam coadministration slightly reduced mean 96‐hour urinary excretion of digoxin (37.6% vs. 30.9% of dose; P < 0.01), but there was no significant difference between treatment conditions in projected total cumulative excretion of digoxin (45.2% vs. 40.9% of dose) or in renal clearance of digoxin (1.23 vs. 1.44 ml/min/kg). Creatinine clearance also did not differ between the control and alprazolam conditions (164 vs. 142 ml/min). Thus therapeutic doses of alprazolam do not significantly alter digoxin clearance in healthy man. Clinical Pharmacology and Therapeutics (1985) 38, 595–598; doi: 10.1038/clpt.1985.230