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Antihypertensive and cardiovascular effects of nitrendipine: A controlled study vs. placebo
Author(s) -
Ferrara Liberato Aldo,
Fasano Maria Luisa,
Simone Giovanni,
Soro Stefano,
Gagliardi Renato
Publication year - 1985
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1985.200
Subject(s) - nitrendipine , medicine , placebo , nifedipine , blood pressure , diastole , ejection fraction , heart rate , cardiology , clinical pharmacology , stroke volume , essential hypertension , cardiac function curve , anesthesia , calcium , pharmacology , heart failure , alternative medicine , pathology
The antihypertensive and cardiovascular effects of nitrendipine, a calcium entry blocker similar to nifedipine, have been evaluated in a double‐blind, placebo‐controlled study in 20 patients with hypertension. At baseline and at the end of the 8‐week period (nitrendipine, 20 mg once a day, or placebo, 1 tablet once a day) the following parameters were measured: systolic and diastolic blood pressure (BP) and heart rate (HR) at rest by an automatic recorder; BP, HR, and cardiac workload (systolic BP × HR) during exercise testing on a bicycle; left ventricular mass (LVMe according to the method of Devereux) and cross‐sectional area (CSA), and main parameters of systolic function (end diastolic volume, end systolic volume [ESV], and ejection fraction [EF]) by M mode echocardiography. There was a significant decrease in BP at rest (163/108 vs. 144/92 mm Hg; P < 0.001) and during exercise in subjects receiving nitrendipine, while placebo did not modify these parameters. LVMe (from 195 to 188 gm; P < 0.01) and CSA (from 20.2 to 19.8 cm 2 ; P < 0.05) were reduced by nitrendipine, which also improved cardiac performance (ESV fell from 44 to 38 ml [P < 0.001] and EF fell from 62% to 66% [P < 0.01]). No effect was observed in the placebo group. Our results indicate that nitrendipine is a powerful antihypertensive agent that also improves cardiac performance and slightly but significantly reduces left ventricular mass. Clinical Pharmacology and Therapeutics (1985) 38 , 434–438; doi: 10.1038/clpt.1985.200