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Antipyrine clearance in pneumonia
Author(s) -
Sonne Jesper,
Døssing Martin,
Loft Steffen,
Andreasen Per Buch
Publication year - 1985
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1985.117
Subject(s) - convalescence , pneumonia , clinical pharmacology , metabolic clearance rate , medicine , drug metabolism , drug , microsome , pharmacology , pharmacokinetics , chemistry , biochemistry , enzyme
Antipyrine clearance was estimated by a one‐sample technique in 14 patients with acute fever and clinical pneumonia. Antipyrine clearance during the acute illness was 31.4 ± 7.6 ml/min ( X ± SD). Fourteen and 28 days later during convalescence, clearance values were higher (47.8 ± 18.9 and 49.2 ± 15.0 ml/ min, respectively). We conclude that microsomal hepatic drug metabolism in adults is impaired during pneumonia. Clinical Pharmacology and Therapeutics (1985) 37 , 701–704; doi: 10.1038/clpt.1985.117