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Disposition of oral lisuride in parkinson's disease
Author(s) -
Burns R Stanley,
Gopinathan G,
Hümpel Michael,
Dorow Rainer,
Calne Donald B
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.76
Subject(s) - lisuride , pharmacokinetics , urine , pharmacology , chemistry , plasma concentration , absorption (acoustics) , radioimmunoassay , clinical pharmacology , disposition , drug , oral administration , oral dose , medicine , dopamine agonist , dopamine , psychology , dopaminergic , social psychology , physics , acoustics
The single and multiple oral dose plasma kinetics of lisuride were followed by a recently developed radioimmunoassay method in 11 patients with Parkinson's disease. A very wide range of plasma drug concentrations resulted from a single dose of 300 µg, as reflected in large interindividual differences in peak concentration (0.27 to 3.30 ng/ml) and AUC after the initial dose (43.1 to 617 ng · min/ml). Absorption was rapid, with a mean time to peak of 39 min. Only 0.05% of the dose was excreted unchanged in urine in 24 hr. There was a 110% increase in apparent oral clearance after 2 to 4 wk of treatment. Clinical Pharmacology and Therapeutics (1984) 35, 548–556; doi: 10.1038/clpt.1984.76