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Plasma 10‐hydroxynortriptyline in elderly depressed patients
Author(s) -
Young Robert C,
Alexopoulos George S,
Shamoian Charles A,
Manley Mark W,
Dhar Amiya K,
Kutt Henn
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.74
Subject(s) - nortriptyline , medicine , plasma concentration , endocrinology , creatinine , plasma levels , blood plasma , pharmacokinetics , chemistry , amitriptyline
Plasma concentrations of nortriptyline (NT) and of unconjugated E‐10‐hydroxynortriptyline (E‐10‐OH‐NT) were measured under steady‐state conditions in elderly (60 yr and older) and young adult (40 yr and younger) patients treated with NT. The two groups received equivalent doses of NT. Plasma NT concentrations of the two groups did not differ, but plasma E‐10‐OH‐NT concentrations were higher in the elderly. The plasma E‐10‐OH‐NT/NT ratios were twice as high in the elderly group. Plasma E‐10‐OH‐NT/NT ratios varied 2000% between individuals in the elderly group but were stable within individuals. Plasma E‐10‐OH‐NT/NT ratios correlated positively but weakly with serum creatinine concentrations. Clinical Pharmacology and Therapeutics (1984) 35, 540–544; doi: 10.1038/clpt.1984.74