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Reduction of digoxin effect during the digoxin‐quinidine interaction
Author(s) -
Das Gopal,
Barr Charles E,
Carlson James
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.36
Subject(s) - digoxin , quinidine , digitalis , drug interaction , pharmacology , medicine , cardiology , heart failure , drug
The effects of the digoxin‐quinidine interaction on cardiac function was examined in healthy subjects. Our results indicate that while serum digoxin levels were elevated, the improved cardiac function due to digoxin declined during combined therapy. Our data also provide an alternate explanation for the changes previously interpreted as “enhanced digitalis effects” during the interaction. Clinical Pharmacology and Therapeutics (1984) 35, 317–321; doi: 10.1038/clpt.1984.36