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Effect of aminoglutethimide on antipyrine, theophylline, and digitoxin disposition in breast cancer
Author(s) -
Lønning Per E,
Kvinnsland Stener,
Bakke Olav M
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.259
Subject(s) - theophylline , digitoxin , aminoglutethimide , pharmacology , chemistry , drug interaction , pharmacokinetics , drug metabolism , medicine , endocrinology , digitalis , concomitant , dexamethasone , cancer , drug , breast cancer , aromatase , digoxin , heart failure
The influence of aminoglutethimide (AG) on antipyrine, theophylline, and digitoxin kinetics was examined. Antipyrine was given as a single test dose before and after 3 mo of AG treatment, whereas theophylline and digitoxin kinetics were investigated at steady state in patients receiving these drugs therapeutically before and after AG therapy. During AG treatment, mean clearance rates for antipyrine, theophylline, and digitoxin increased by 81%, 32%, and 109%. Together with earlier reports of effects of AG on warfarin and dexamethasone disposition and on its own metabolism, these findings indicate that AG is a potent inducer of drug metabolizing microsomal monooxygenases of the liver. Since many drugs known to be metabolized by this enzyme system are frequently used for concomitant conditions in patients with breast cancer, interactions with AG are to be expected. Clinical Pharmacology and Therapeutics (1984) 36 , 796–802; doi: 10.1038/clpt.1984.259