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Evaluation of methods to estimate cigarette smoke uptake
Author(s) -
Hopkins R,
Wood Lesley E,
Sinclair N M
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.258
Subject(s) - cotinine , nicotine , carboxyhemoglobin , smoke , tobacco smoke , cigarette smoke , chemistry , sidestream smoke , saliva , thiocyanate , physiology , medicine , toxicology , carbon monoxide , biochemistry , environmental health , organic chemistry , biology , catalysis
Exposure to tobacco smoke is measured by a variety of invasive and noninvasive techniques. Our purpose was to examine how well some of these measures correlated when obtained simultaneously from the same subjects. On three occasions, six subjects were studied while they were smoking a single cigarette after 24 hr of abstinence. There were positive correlations between increases in heart rate and plasma nicotine concentrations and between percentage carboxyhemoglobin and exhaled carbon monoxide. Although residual cotinine was readily detected in samples of plasma before the subjects smoked, there was an increase in mean levels, with a peak approximately 1 hr after smoking. Urinary concentrations of nicotine, cotinine, and nicotine‐1′‐N‐oxide and thiocyanate levels in plasma and saliva were essentially unchanged by smoking a single cigarette. Data on smoke generation and nicotine retention in cigarette butts correlated poorly with all other measures of smoke uptake. Clinical Pharmacology and Therapeutics (1984) 36 , 788–795; doi: 10.1038/clpt.1984.258