Premium
Nifedipine and alpha adrenoceptor antagonism
Author(s) -
Murphy Michael B,
Brown Morris J,
Scriven Anthony J I,
Heavey Denis J,
Dollery Colin T
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.252
Subject(s) - methoxamine , nifedipine , antagonist , antagonism , angiotensin ii , pharmacology , clinical pharmacology , placebo , norepinephrine , blood pressure , medicine , endocrinology , agonist , receptor , calcium , alternative medicine , pathology , dopamine
The effects of nifedipine and placebo on the pressor responses to methoxamine, α‐methylnorepinephrine, and angiotensin II were compared in normal subjects. Nifedipine shifted the pressor dose‐response curves of all three agonists to the right. The dose ratios of the three agonists were of the same order. Thus in contrast to the findings in animals, nifedipine is not a selective α 2 ‐adrenergic antagonist in man, although it may lower blood pressure partly by antagonism of norepinephrine and angiotensin II. Clinical Pharmacology and Therapeutics (1984) 36 , 745–749; doi: 10.1038/clpt.1984.252