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Kinetics of digitoxin and the bis‐ and monodigitoxosides of digitoxigenin in renal insufficiency
Author(s) -
Graves Penelope E,
Fenster Paul E,
MacFarland Ronald T,
Marcus Frank I,
Perrier Donald
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.229
Subject(s) - digitoxin , digitoxigenin , kinetics , chemistry , medicine , pharmacology , digoxin , stereochemistry , physics , heart failure , glycoside , quantum mechanics
The kinetics of digitoxin and two of its major metabolites, the bis‐ and monodigitoxosides of digitoxigenin, were determined in six subjects with renal insufficiency and compared to those in six age‐ and sex‐matched normal control subjects. No significant differences between the two groups were found in elimination t½, total body clearance, or volume of distribution. Average renal clearances of all three drugs were reduced in subjects with renal failure, but the differences were significant only in the case of digitoxin. The bis‐digitoxoside of digitoxigenin has kinetic properties that offer clinical advantages. Clinical Pharmacology and Therapeutics (1984) 36, 607–612; doi: 10.1038/clpt.1984.229