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Multiple‐dose ciprofloxacin kinetics in normal subjects
Author(s) -
Aronoff George E,
Kenner C H,
Sloan R S,
Pottratz S T
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.192
Subject(s) - ciprofloxacin , kinetics , medicine , pharmacology , chemistry , antibiotics , biochemistry , physics , quantum mechanics
To determine multiple‐dose kinetics of the quinoline carboxylic acid derivative ciprofloxacin, we gave 12 normal subjects ciprofloxacin, 250 mg by mouth every 12 hr for 13 doses. Plasma concentrations were measured by HPLC after the first, seventh, and thirteenth doses. Peak and trough plasma concentrations were measured daily. Ciprofloxacin was rapidly absorbed from the gastrointestinal tract and reached maximum serum concentrations about 1 hr after dosing. Ciprofloxacin elimination t½ increased from 3.71 hr after the first dose to 6.51 hr after the thirteenth dose (P < 0.05). Apparent plasma clearance decreased from 0.823 to 0.629 l/kg/hr because of decreased nonrenal clearance. Drug cumulation did not occur throughout the experiment. We conclude that concentrations of ciprofloxacin in excess of the minimum inhibitory concentrations for many important pathogens can be achieved in plasma and that controlled clinical trials of ciprofloxacin efficacy in selected systemic infections are warranted. Clinical Pharmacology and Therapeutics (1984) 36, 384–388; doi: 10.1038/clpt.1984.192