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Effect of oral amrinone on platelet function and survival
Author(s) -
Brandt John T,
Miller Linda,
Hermiller James,
Unverferth Donald V,
Leier Carl V
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.172
Subject(s) - amrinone , platelet , medicine , clinical pharmacology , clinical trial , oral administration , pharmacology , cardiology , hemodynamics
Amrinone is a cardiotonic agent associated with reversible thrombocytopenia in 20% to 50% of patients. The mechanism of thrombocytopenia is not known and it is not clear whether this effect represents a high‐frequency idiosyncratic reaction or an overt manifestation of a toxic effect on platelet survival. We prospectively evaluated the effect of oral amrinone on platelet function and survival in seven subjects who participated in a clinical trial of chronic oral amrinone therapy. There was no consistent effect on either platelet function or platelet survival. Data suggest that amrinone does not have a uniform effect on platelet survival and that the development of thrombocytopenia may represent an idiosyncratic reaction. Clinical Pharmacology and Therapeutics (1984) 36, 260–264; doi: 10.1038/clpt.1984.172