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Cimetidine kinetics during resuscitation from burn shock
Author(s) -
Ziemniak John A,
Watson William A,
Saffle Jeffrey R,
Smith Ian L,
Russo John,
Warden Glenn D,
Schentag Jerome J
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.167
Subject(s) - resuscitation , shock (circulatory) , cimetidine , medicine , anesthesia , intensive care medicine , pharmacology
Severely burned patients suffer from rapidly changing metabolic and hemodynamic abnormalities that could alter drug kinetics. The kinetics of cimetidine, commonly used in the prophylaxis of acute stress erosions, were studied during fluid resuscitation of 11 patients with mean burn sizes of 45% total body surface area. Six patients were studied after the completion of fluid resuscitation. Total clearance, steady‐state volume of distribution, and cimetidine t½ did not change between the early period after burn and after fluid resuscitation, but before the completion of fluid resuscitation patients had lower renal and greater nonrenal cimetidine clearance than after resuscitation. The increase in nonrenal cimetidine clearance resulted in decreased urinary recovery of unchanged drug, 50.7% ± 14% during fluid resuscitation and 81.0% ± 6% after resuscitation. Clinical Pharmacology and Therapeutics (1984) 36, 228–233; doi: 10.1038/clpt.1984.167