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The diltiazem‐digoxin interaction
Author(s) -
Rameis Heinz,
Magometschnigg Dieter,
Ganzinger Ulrich
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.160
Subject(s) - diltiazem , digoxin , antagonist , crossover study , volume of distribution , pharmacology , drug interaction , clinical pharmacology , chemistry , pharmacokinetics , steady state (chemistry) , medicine , heart failure , calcium , placebo , receptor , alternative medicine , pathology
To study the interaction between the calcium antagonist diltiazem and digoxin, a randomized crossover trial under steady‐state conditions was carried out in 24 healthy male subjects. Diltiazem with digoxin induced an average increase of steady‐state plasma digoxin concentration and AUC over 48 hr of 22.4%. This is caused by the prolongation of elimination t½ from 36.2 ± 11.2 to 44.5 ± 11.5 hr (X̄ ± SD) and the impairment of total digoxin clearance, dropping from 146.6 ± 37.9 to 107.9 ± 18.4 ml/min. Average reduction in renal clearance (from 102.1 ± 35.5 to 85.5 ± 42.7 ml/min) was not statistically reproducible. Apparent volume of distribution was not relevantly altered. Diltiazem kinetics did not change significantly when digoxin was concurrently given. Clinical Pharmacology and Therapeutics (1984) 36, 183–189; doi: 10.1038/clpt.1984.160