Disposition of intravenous glycofurol: Effect of hepatic cirrhosis | Zendy

Bury Ross W | Zendy; Breen Kerry J | Zendy; Desmond Paul V | Zendy; Raymond Kenneth | Zendy; Mashford Maurice L | Zendy

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Disposition of intravenous glycofurol: Effect of hepatic cirrhosis

Author(s) -

Bury Ross W,

Breen Kerry J,

Desmond Paul V,

Raymond Kenneth,

Mashford Maurice L

Publication year - 1984

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.1984.143

Subject(s) - cirrhosis , disposition , clinical pharmacology , volume of distribution , medicine , pharmacokinetics , pharmacology , metabolic clearance rate , distribution (mathematics) , gastroenterology , psychology , social psychology , mathematical analysis , mathematics

The disposition of intravenous glycofurol, a solvent for some drugs, was followed in nine male patients with hepatic cirrhosis. In comparison with age‐matched controls, glycofurol clearance in the patients with cirrhosis was reduced 43% and terminal t½ was prolonged 103%. There was no significant difference between the cirrhotic and control groups in volume of distribution. Clinical Pharmacology and Therapeutics (1984) 36, 82–84; doi: 10.1038/clpt.1984.143

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