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Disposition of intravenous glycofurol: Effect of hepatic cirrhosis
Author(s) -
Bury Ross W,
Breen Kerry J,
Desmond Paul V,
Raymond Kenneth,
Mashford Maurice L
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.143
Subject(s) - cirrhosis , disposition , clinical pharmacology , volume of distribution , medicine , pharmacokinetics , pharmacology , metabolic clearance rate , distribution (mathematics) , gastroenterology , psychology , social psychology , mathematical analysis , mathematics
The disposition of intravenous glycofurol, a solvent for some drugs, was followed in nine male patients with hepatic cirrhosis. In comparison with age‐matched controls, glycofurol clearance in the patients with cirrhosis was reduced 43% and terminal t½ was prolonged 103%. There was no significant difference between the cirrhotic and control groups in volume of distribution. Clinical Pharmacology and Therapeutics (1984) 36, 82–84; doi: 10.1038/clpt.1984.143