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Effect of penbutolol and propranolol on normal airway response to salbutamol
Author(s) -
Warren J B,
Monaghan A T,
Clark T J H
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.137
Subject(s) - salbutamol , propranolol , placebo , medicine , anesthesia , airway , asthma , pharmacology , alternative medicine , pathology
The specific airway conductance (sGaw) response of eight normal men to inhaled salbutamol, 200, 600, and 1800 µg, was measured on 3 separate days. On each occasion subjects received either placebo, long‐acting propranolol (160 mg), or penbutolol (40 mg) orally in a double‐blind manner after baseline lung function determination. After placebo, mean sGaw rose from a baseline of 2.07±0.15 to 2.81±0.25 kPa −1 · sec −1 after 200 µg salbutamol. There was little further airway dilation with higher doses of salbutamol. With long‐acting propranolol, there was no significant airway dilation after 200 µg salbutamol but there was after 600 and 1800 µg inhaled salbutamol; baseline sGaw rose from 2.02±0.17 to 2.70±0.28 and 2.95±0.32 kPa −1 · sec −1 . Penbutolol prevented any significant airway dilation with all doses of salbutamol. Penbutolol at the doses used appears to be a more potent blocker of β 2 ‐receptors than does propranolol. Clinical Pharmacology and Therapeutics (1984) 36, 47–50; doi: 10.1038/clpt.1984.137