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Effect of nifedipine on serum digoxin concentration and renal digoxin clearance
Author(s) -
Schwartz Janice B,
Migliore Philip J
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.133
Subject(s) - digoxin , nifedipine , placebo , medicine , renal function , endocrinology , heart failure , calcium , alternative medicine , pathology
Nifedipine has been reported either to decrease or not to affect digoxin elimination. We studied the effect of oral nifedipine on steady‐state digoxin concentrations and renal clearance in 20 healthy male subjects. After 2 wk of digitalization, all received digoxin, 0.375 mg a day, with placebo for 2 wk, then digoxin and nifedipine, 18.5±4 mg every 8 hr, for 2 wk, and then digoxin with placebo for 2 wk. Mean (±SD) digoxin concentrations of 0.74±0.20 and 0.75±0.25 ng/ml on placebo were not altered by nifedipine (0.77±0.23 ng/ml). Digoxin clearance was 2.2±0.6 and 2.7±0.8 ml/kg/min on placebo and 2.5±0.6 ml/kg/min on nifedipine. No change in pharmacologic effect of digoxin by nifedipine was observed, but mean blood pressure was lower and heart rates were accelerated. These data indicate that oral nifedipine does not alter digoxin concentrations or decrease renal clearance in healthy subjects. Clinical Pharmacology and Therapeutics (1984) 36, 19–24; doi: 10.1038/clpt.1984.133