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Digoxin‐rifampin interaction
Author(s) -
Gault Henry,
Longerich Linda,
Dawe Madonna,
Fine Adrian
Publication year - 1984
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1984.106
Subject(s) - digoxin , clinical pharmacology , medicine , pharmacology , serum concentration , therapeutic index , drug , heart failure
Digoxin doses required to maintain therapeutic serum concentrations rose substantially in two patients dependent on dialysis with the commencement of rifampin therapy. When rifampin was discontinued, doses fell to requirements before rifampin. Serum digoxin concentration may fall to ineffective levels with rifampin therapy and rise to potentially toxic levels when rifampin is discontinued. Clinical Pharmacology and Therapeutics (1984) 35 , 750–754; doi: 10.1038/clpt.1984.106