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Local aspirin analgesia in the oral cavity
Author(s) -
Loch Walter E E,
Wenger Alvin P,
Loch Mary H,
Loch W Eric,
Reiriz Helen M L
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.87
Subject(s) - aspirin , analgesic , anesthesia , oral cavity , medicine , clinical pharmacology , tongue , pharmacology , dentistry , pathology
Aspirin solution applied locally to the oral cavity produces an analgesic effect on pain induced by electrical stimuli and by knife prick. Spontaneous pain is also relieved. The effect is of a local nature and can be terminated by rinsing the mouth with water, indicating that there is only a loose bond between aspirin and the mucosa. The local nature is also demonstrated by the lack of analgesia in areas of the tongue where exposure to aspirin solution is prevented by separation with a rubber‐dam. Clinical Pharmacology and Therapeutics (1983) 33, 642–648; doi: 10.1038/clpt.1983.87