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Chronopharmacology of amitriptyline
Author(s) -
Nakano Shigeyuki,
Hollister Leo E
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.61
Subject(s) - evening , morning , amitriptyline , bioavailability , pharmacology , clinical pharmacology , sedation , medicine , drug , absorption (acoustics) , absorption rate , pharmacokinetics , anesthesia , chemistry , chromatography , astronomy , acoustics , physics
Side effects of decreased salivation and sedation were more marked when a single dose of amitriptyline was taken orally in the morning than in the evening. These dynamic differences were due to alteration in kinetics. Absorption of the drug was more rapid in the morning, although other kinetic parameters, especially total bioavailability, were unchanged. Thus, in the case of this drug, chronopharmacologic differences were due to a change in rate of absorption. The present practice of giving a single dose of drug in the evening is justified on the basis that it induces fewer side effects without a loss in therapeutic efficacy. Clinical Pharmacology and Therapeutics (1983) 33, 453–459; doi: 10.1038/clpt.1983.61