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Diurnal variation in prednisolone kinetics
Author(s) -
English Judie,
Dunne Michael,
Marks Vincent
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.49
Subject(s) - prednisolone , morning , bioavailability , dosing , diurnal temperature variation , pharmacology , pharmacokinetics , plasma concentration , chemistry , kinetics , clinical pharmacology , corticosteroid , medicine , physics , atmospheric sciences , quantum mechanics , geology
Plasma concentrations of free and total prednisolone were measured after oral doses at four time points to investigate the possibility of a diurnal variation in the drug's kinetics. There were marked differences in plasma prednisolone concentrations, clearance rates, and bioavailability of both free and total fractions at different times of the day. Changes in the protein binding characteristics of prednisolone with clock time resulted in marked differences between the kinetics of free and total prednisolone. It is recommended that for maximum efficacy and minimum toxicity prednisolone therapy be confined to once‐daily dosing in the morning. Clinical Pharmacology and Therapeutics (1983) 33, 381–385; doi: 10.1038/clpt.1983.49