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Glucose and lipid metabolism during acebutolol and propranolol therapy of angina in nondiabetic patients
Author(s) -
Birnbaum Joseph,
DiBianco Robert,
Becker Kenneth L,
Muesing Richard,
Costello Rebecca B,
Singh Steven N,
Gottdiener John S,
Fletcher Ross D
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.36
Subject(s) - acebutolol , propranolol , endocrinology , medicine , diabetes mellitus , tolbutamide , beta blocker , clinical pharmacology , pharmacology , heart failure
The metabolic effects of acebutolol, a cardioselective beta‐adrenergic blocker, and of propranolol, a nonselective beta blocker, were evaluated. Our subjects were 20 men with chronic stable angina; none had diabetes. An initial 4‐wk, single‐blind control phase was followed by two drug treatment periods, each a 3‐wk double‐blind titration phase (using increasing doses of acebutolol or propranolol), followed by a 5‐wk double‐blind maintenance phase. Metabolic studies were performed at the end of the control and maintenance phases. Propranolol induced elevation in basal serum glucose concentrations and both propranolol and acebutolol decreased glucose tolerance at 2.5 and 3 hr. There was no noticeable effect on insulin secretion by either drug. Neither propranolol nor acebutolol induced hyperlipidemia. There was a small decrease in total serum cholesterol after propranolol. Both drugs decreased low‐density lipoprotein cholesterol. No effects were noted on the levels of serum triglycerides, high‐density lipoprotein cholesterol, or free fatty acids. Clinical Pharmacology and Therapeutics (1983) 33, 294–300; doi: 10.1038/clpt.1983.36