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Indenolol in hypertension
Author(s) -
Sega Roberto,
Mailland Federico,
Damiani Eugenia,
Groothold Gisela,
Libretti Arnaldo
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.35
Subject(s) - supine position , heart rate , blood pressure , medicine , placebo , bradycardia , cardiology , anesthesia , mean arterial pressure , diastole , alternative medicine , pathology
After a complete washout 14 hypertensive inpatients were given placebo for 3 days. Undistinguishable 30‐ or 60‐mg indenolol tablets were then given twice daily for 14 days in a double‐blind, randomized manner. Supine and standing arterial pressure and heart rate were measured at rest three times a day. Indenolol decreased systolic and diastolic arterial pressure as well as heart rate in subjects in supine and standing positions. Placebo had no effect. The effect of indenolol on systolic arterial pressure was dose and time related, but independent of the intensity of hypertension. No dose‐effect relationship was found on diastolic arterial pressure. Decrease of heart rate was dose and time related, although bradycardia was never noted. Indenolol was well tolerated. Clinical Pharmacology and Therapeutics (1983) 33, 289–293; doi: 10.1038/clpt.1983.35