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Atenolol interaction with aspirin, allopurinol, and ampicillin
Author(s) -
SchäferKorting Monika,
Kirch Wilhelm,
Axthelm Thilo,
Köhler Hans,
Mutschler Ernst
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.34
Subject(s) - atenolol , ampicillin , aspirin , pharmacology , bioavailability , allopurinol , medicine , chemistry , blood pressure , antibiotics , biochemistry
Atenolol kinetics were investigated in six healthy subjects after 100 mg orally, as monotherapy a 6‐day treatment began 48 hr later. After a therapy‐free interval of 4 wk, the same subjects received the same dose of atenolol with 1 gm ampicillin, 500 mg aspirin, and with 300 mg allopurinol. Allopurinol and aspirin did not substantially alter the kinetics of atenolol. After a single oral dose of 100 mg atenolol combined with 1 gm ampicillin, the bioavailability of atenolol was reduced to 36 ± 5% compared to 60 ± 8% after monotherapy. During long‐term treatment with atenolol and ampicillin the bioavailability of atenolol fell to 24% (P < 0.01). Mean peak plasma levels were lowered from 511 ±59 ng/ml on monotherapy to 344 ± 33 ng/ml after the combination with ampicillin. The area under the plasma level–time curve, mean steady‐state concentration, and urinary recovery were reduced, also. Twelve hours after 100 mg atenolol and 1 gm ampicillin, exercise tachycardia was significantly higher than after atenolol alone. During the 4‐wk treatment in six hypertensive patients blood pressure levels of those on atenolol alone were not different from those on the combination therapy with ampicillin. Clinical Pharmacology and Therapeutics (1983) 33, 283–288; doi: 10.1038/clpt.1983.34