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6β‐Hydroxycortisol in random urine samples as an indicator of enzyme induction
Author(s) -
Saenger Paul
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.255
Subject(s) - urine , enzyme inducer , enzyme , chemistry , chromatography , pharmacology , medicine , biochemistry
6β‐Hydroxycortisol (6β‐0HF) is a major cortisol metabolite formed primarily in the hepatic reticulum by mixed‐function oxygenases. Changes in 6β‐OHF may be used to detect enzyme induction by drugs or disease. Excretion of 6β‐OHF must be corrected for change in urinary free cortisol (FF) excretion to allow for changes in cortisol production. We report the absence of circadian changes in 6β‐OHF/FF ratios. Thus random measurements of 6β‐OHF/FF ratios may be used to detect enzyme induction. This approach greatly simplifies noninvasive screening for enzyme induction. Clinical Pharmacology and Therapeutics (1983) 34 , 818–821; doi: 10.1038/clpt.1983.255