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Predictability of antihypertensive efficacy of selective β 1 blockers
Author(s) -
Volpe Massimo,
Trimarco Bruno,
Ricciardelli Bruno,
Cuocolo Alberto,
Veniero Anna Maria,
De Luca Nicola,
Condorelli Mario
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.246
Subject(s) - chronotropic , metoprolol , blood pressure , atenolol , heart rate , plasma renin activity , hemodynamics , medicine , essential hypertension , aldosterone , cardiology , cardiac output , renin–angiotensin system
The possibility that hemodynamic and biohumoral factors may help predict the antihypertensive effectiveness of selective β 1 blockers was investigated. The effects of 3 wk of treatment with two selective β 1 blockers, metoprolol and atenolol, were observed in 54 patients with mild or moderate essential hypertension. No significant difference between the hemodynamic effects of the two drugs was found. The percent fall in systolic blood pressure induced by the two correlated strongly with the pretreatment values of the chronotropic response to isoproterenol and with the pretreatment values of cardiac output, heart rate, and plasma renin activity (PRA). There was no correlation between the decrease in systolic blood pressure induced and initial 24‐hr urinary catecholamine output, total peripheral resistance, and plasma aldosterone. Percent fall in diastolic blood pressure correlated only with the pretreatment levels of PRA. Our results support the view that the hypotensive effect of β 1 blockers are predictable on the basis of the pretreatment values of chronotropic response to isoproterenol, PRA, heart rate, and cardiac output. Clinical Pharmacology and Therapeutics (1983) 34 , 758–763; doi: 10.1038/clpt.1983.246