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Clonidine in patients with diabetes and mild hypertension
Author(s) -
Guthrie Gordon P,
Miller Ralph E,
Kotchen Theodore A,
Koenig Sue H
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.239
Subject(s) - clonidine , medicine , glycemic , diabetes mellitus , blood pressure , endocrinology , urinary system
Clonidine has been reported to adversely affect glucose tolerance in experimental animals and normal man. We assessed its short‐ and long‐term effects in 10 patients with both mild hypertension and diabetes mellitus. Patients were studied before and 10 wk after treatment with 0.1 mg clonidine twice daily, which induced reductions in blood pressure (from 148 ± 5/93 ± 2 mm H g sitting, to 125 ± 4/80 ± 2) and control of hypertension in all patients. Clonidine increased the glycemic response to intravenous glucose (incremental glucose AU C from 161 ± 13 to 184 ± 14) but did not significantly change long‐term diabetic control as assessed by weekly fasting serum glucose, glycosylated hemoglobin, and 24‐hr urinary glucose excretions before and after treatment. We conclude that low‐dose clonidine controlled blood pressure and impaired the response to an acute glucose challenge in mildly hypertensive, type II diabetic patients but did not adversely affect diabetic control over 10 wk. Clinical Pharmacology and Therapeutics (1983) 34 , 713–717; doi: 10.1038/clpt.1983.239