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Ibuprofen and acetaminophen kinetics when taken concurrently
Author(s) -
Wright C Eugene,
Antal Edward J,
Gillespie William R,
Albert Kenneth S
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.237
Subject(s) - ibuprofen , acetaminophen , crossover study , bioavailability , kinetics , chemistry , high performance liquid chromatography , pharmacokinetics , chromatography , pharmacology , medicine , physics , alternative medicine , pathology , quantum mechanics , placebo
We evaluated kinetics of ibuprofen and acetaminophen taken concurrently by 20 healthy adults in a randomized crossover design. Steady‐state blood levels of ibuprofen and acetaminophen were measured by gas‐liquid chrornatography and HPLC. There were no significant differences in any of the ibuprofen serum concentrations, but there were differences in acetaminophen serum concentrations in 5 of 19 sampling times. When bioavailability and kinetic parameters for both drugs were compared, there were no significant differences. Our data demonstrate that steady‐state kinetics of ibuprofen and acetaminophen are not changed when taken concurrently. Clinical Pharmacology and Therapeutics (1983) 34, 707–710; doi: 10.1038/clpt.1983.237