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Fentanyl sequestration in lungs during cardiopulmonary bypass
Author(s) -
Bentley John B,
III Thomas J Conahan,
Cork Randall C
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.235
Subject(s) - fentanyl , cardiopulmonary bypass , hematocrit , medicine , anesthesia , theophylline , pulmonary artery , pco2 , perfusion , cardiac surgery , cardiac output , radial artery , artery , cardiology , hemodynamics
Serum fentanyl concentrations were measured before, during, and after cardiopulmonary bypass and correlated with changes in total protein, albumin, hematocrit, pH, and PCO 2 in five patients undergoing cardiac surgery. Serum fentanyl concentrations, total protein, albumin, and hematocrit declined with initiation of bypass but remained unchanged thereafter. PCO 2 and pH did not change. In an additional seven patients, simultaneous pulmonary‐artery and radial‐artery fentanyl concentrations were measured. During bypass, when little, if any blood flowed through the pulmonary circulation, pulmonary artery fentanyl concentrations were higher than systemic arterial concentrations, but when lung ventilation and perfusion were restored, radial artery concentrations rose and pulmonary artery concentrations fell, indicating fentanyl sequestration in the lungs during bypass. Clinical Pharmacology and Therapeutics (1983) 34, 703–706; doi: 10.1038/clpt.1983.235