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Ranitidine kinetics in chronic renal impairment
Author(s) -
Zech Paul Y,
Chau Nguyen Ph,
Pozet Nicole,
Labeeuw Michel,
HadjAissa Aoumeur
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.230
Subject(s) - ranitidine , kinetics , medicine , pharmacology , urology , gastroenterology , quantum mechanics , physics
The effects of moderate to severe renal impairment on kinetics of the H 2 ‐blocker ranitidine were investigated in 16 patients divided into two groups. Mean inulin clearance (Cl In ) was 35 ± 18.3 ml/min/ 1.73 m 2 in group I and 7.4 ± 3.5 ml/min/1.73 m 2 in group II. Each patient received a single 150‐mg oral dose of ranitidine. Values determined were maximum plasma concentration (MC) and time of occurrence, AUC, elimination t½ (t½β), total amount of unchanged ranitidine recovered in urine, and ranitidine renal clearance (Cl R ). MC values were higher and longer delayed than values reported in subjects with normal renal function. The t½β was longer in group I and group II and correlated with the degree of renal impairment. The amount of ranitidine excreted within the first 24 hr decreased (18% of the dose in group I and 6% of the dose in group II), and Cl R correlated strongly with Cl In , indicating that the observed changes in ranitidine kinetics are mainly related to changes in its renal excretion. Clinical Pharmacology and Therapeutics (1983) 34, 667–672; doi: 10.1038/clpt.1983.230