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Vitamin K‐dependent proteins and anticonvulsant medication
Author(s) -
Keith David A,
Gundberg Caren M,
Japour Anthony,
Alvarez Norberto,
Gallop Paul M
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.209
Subject(s) - phenytoin , phenobarbital , anticonvulsant , clinical pharmacology , pharmacology , anticonvulsant drugs , medicine , vitamin , epilepsy , chemistry , endocrinology , psychiatry
Certain anticonvulsant drugs, especially phenytoin and phenobarbital, interfere with vitamin K metabolism as indicated by a raised serum osteocalcin level. This finding may be of importance in the pathogenesis of side effects of these medications. Clinical Pharmacology and Therapeutics (1983) 34, 529–532; doi: 10.1038/clpt.1983.209