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Midazolam kinetics in women of two age groups
Author(s) -
Avram Michael J,
Fragen Robert J,
Caldwell Nancy J
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.205
Subject(s) - midazolam , volume of distribution , kinetics , benzodiazepine , pharmacokinetics , chemistry , nitrous oxide , distribution (mathematics) , anesthesia , hypnotic , fentanyl , pharmacology , medicine , biochemistry , mathematics , mathematical analysis , physics , receptor , quantum mechanics , sedation
Midazolam kinetics were determined in 11 younger (22 to 30 yr) and 11 older (50 to 60 yr) women to determine age‐related differences in the kinetics of this water‐soluble benzodiazepine. Midazolam, 0.2 mg/kg, was injected intravenously over 30 sec for induction of anesthesia that was maintained with 67% nitrous oxide in oxygen and intravenous fentanyl doses. There were no differences between the groups with respect to awakening times or plasma concentrations. Midazolam kinetics were described by a three‐compartment open mamillary model. The only differences were small increases in the slow and total volumes of distribution in the older women. The kinetics we determined, including the steady‐state volume of distribution of 1.23 l/kg and the elimination clearance of 419 ml/min, are in excellent agreement with those reported by others. Our data suggest that midazolam has advantages over other benzodiazepines, not only because of its water solubility and shorter elimination t½, but also because of little change in its kinetics with age. Clinical Pharmacology and Therapeutics (1983) 34, 505–508; doi: 10.1038/clpt.1983.205