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Effects of lorazepam and its withdrawal on sleep, performance, and subjective state
Author(s) -
Walsh James K,
Schweitzer Paula K,
Parwatikar Sadashiv
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.203
Subject(s) - lorazepam , anxiety , insomnia , psychology , hypnotic , clinical pharmacology , placebo , anesthesia , sleep (system call) , polysomnography , medicine , psychiatry , electroencephalography , pharmacology , alternative medicine , pathology , computer science , operating system
The effects of 3 mg lorazepam on polysomnographic recordings, performance, anxiety, and perceived sleep were examined. Six insomniac subjects slept in the sleep laboratory for 18 consecutive nights after having taken placebo or lorazepam. Polysomnographic data and subjective reports indicated hypnotic efficacy in terms of sleep initiation and maintenance. There was some evidence of rebound insomnia after drug withdrawal, although it was not evident from all measures. Clear performance decrements occurred during lorazepam use. Clinical Pharmacology and Therapeutics (1983) 34, 496–500; doi: 10.1038/clpt.1983.203