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On the question of dose‐dependent chloroquine elimination of a single oral dose
Author(s) -
Gustafsson Lars L,
Rombo Lars,
Alván Gunnar,
Björkman Anders,
Lind Margareta,
Walker Oladapo
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.183
Subject(s) - chloroquine , dosing , oral dose , pharmacology , clinical pharmacology , pharmacokinetics , oral administration , medicine , chemistry , immunology , malaria
Subjects (n = 45) were randomly given single oral doses of 2 (n = 11), 3 (n = 9), 5 (n = 8), 10 (n = 10), or 15 mg/kg (n = 7) chloroquine base. Chloroquine was analyzed by HPLC in serum samples taken at 3 to 168 hr after dosing. AUCs, calculated for the time period of 0 to 168 hr were proportional to the doses. Mean AUC value increased 6.7 times when the dose was increased 7.5 times (from 2 to 15 mg/kg). These data do not support the existence of significant capacity‐limited chloroquine elimination within the dose range studied. Clinical Pharmacology and Therapeutics (1983) 34 , 383–385; doi: 10.1038/clpt.1983.183