On the question of dose‐dependent chloroquine elimination of a single oral dose | Zendy

Gustafsson Lars L | Zendy; Rombo Lars | Zendy; Alván Gunnar | Zendy; Björkman Anders | Zendy; Lind Margareta | Zendy; Walker Oladapo | Zendy

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On the question of dose‐dependent chloroquine elimination of a single oral dose

Author(s) -

Gustafsson Lars L,

Rombo Lars,

Alván Gunnar,

Björkman Anders,

Lind Margareta,

Walker Oladapo

Publication year - 1983

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.1983.183

Subject(s) - chloroquine , dosing , oral dose , pharmacology , clinical pharmacology , pharmacokinetics , oral administration , medicine , chemistry , immunology , malaria

Subjects (n = 45) were randomly given single oral doses of 2 (n = 11), 3 (n = 9), 5 (n = 8), 10 (n = 10), or 15 mg/kg (n = 7) chloroquine base. Chloroquine was analyzed by HPLC in serum samples taken at 3 to 168 hr after dosing. AUCs, calculated for the time period of 0 to 168 hr were proportional to the doses. Mean AUC value increased 6.7 times when the dose was increased 7.5 times (from 2 to 15 mg/kg). These data do not support the existence of significant capacity‐limited chloroquine elimination within the dose range studied. Clinical Pharmacology and Therapeutics (1983) 34 , 383–385; doi: 10.1038/clpt.1983.183

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