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Evaluation of current clinical trial methodology in analgesimetry based on experts' opinions and analysis of several analgesic studies
Author(s) -
Sriwatanakul Kampon,
Lasagna Louis,
Cox Christopher
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.168
Subject(s) - analgesic , clinical pharmacology , medicine , clinical trial , statistical analysis , medical physics , clinical practice , alternative medicine , pharmacology , physical therapy , statistics , mathematics , pathology
There is general agreement that the controlled clinical trial is the best method for analgesic evaluation. Current practice in clinical analgesimetry, however, varies considerably with regard to design, measurement of pain, and statistical analysis. We attempted to assess the degree of this diversity by a questionnaire survey of a sample of investigators who are currently conducting clinical pain studies. To examine how various statistical methods perform in practice, we reanalyzed data from four of our published analgesic studies using a number of standard methods. Clinical Pharmacology and Therapeutics (1983) 34 , 277–283; doi: 10.1038/clpt.1983.168