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Triazolam concentration‐effect relationships in healthy subjects
Author(s) -
Baktir G,
Fisch H U,
Huguenin P,
Bircher J
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.152
Subject(s) - triazolam , digit symbol substitution test , hypnotic , psychology , clinical pharmacology , pharmacology , benzodiazepine , anesthesia , medicine , placebo , receptor , alternative medicine , pathology
Triazolam was used to study the plasma concentration‐effect relationship of a benzodiazepine because it has a very short plasma t½. A standard hypnotic dose of 0.25 mg was given by mouth to six healthy subjects, and blood samples were drawn when the subjects had to perform a battery of psychologic tests. Only the digit‐symbol substitution test, the card‐sorting test according to numbers, and the visual analog scale (energetic‐lethargic) gave significant results. Analysis of the concentration‐effect relationship in individuals indicated a wide scatter of the data. Mean values revealed a trend for a learning effect in the card‐sorting test. The results are consistent with the hypothesis that triazolam is well suited for a study of concentration‐effect relationships, but better psychologic tests would be desirable. Clinical Pharmacology and Therapeutics (1983) 34 , 195–201; doi: 10.1038/clpt.1983.152