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Dose proportionality of amrinone
Author(s) -
Edelson Jerome,
Park George B,
Angellotti Jon,
Kershner Ronald P,
Ryan Jerome J,
McMahon F Gilbert
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.151
Subject(s) - clinical pharmacology , crossover study , chemistry , plasma concentration , amrinone , pharmacology , mathematics , medicine , inotrope , placebo , alternative medicine , pathology
Arminone was given to 18 healthy subjects in doses of 75, 150, and 225 mg in a randomized crossover design. Plasma levels were shown to rise in proportion to dose. The mean plasma AUC, extrapolated to infinite time, was determined for each dose level; the values obtained were 4, 8.18, and 12.35 μg · hr/ml for the 75‐, 150‐, and 225‐mg doses. Mean maximum observed plasma concentrations were 1.03, 1.74, and 2.58 μg/ml. At higher doses the extrapolated AUC is more variable, but it is linear over the range of 0.73 to 3.81 mg/kg. The apparent first‐order terminal elimination rate is not dose dependent and corresponds to a t½ of 3.85 hr. Clinical Pharmacology and Therapeutics (1983) 34 , 190–194; doi: 10.1038/clpt.1983.151