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Hemodynamic effects of isometric exercise and mental arithmetic in hypertension treated with selective and nonselective β‐blockade
Author(s) -
Houben Harry,
Thien Theo,
Boo Theo,
Lemmens Wim,
Binkhorst Rob,
't Laar Albert
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.147
Subject(s) - metoprolol , propranolol , hemodynamics , heart rate , placebo , blood pressure , medicine , isometric exercise , anesthesia , blockade , crossover study , acebutolol , mental arithmetic , forearm , cardiology , surgery , alternative medicine , receptor , pathology
Hypertensive patients have an unfavorable pressor response to exogenous epinephrine during nonselective β‐blockade. We studied hemodynamics during epinephrine release induced by handgrip exercise and mental arithmetic to examine the clinical relevance of this phenomenon. Twenty‐two hypertensive patients were examined in a double‐blind crossover experiment with placebo, propranolol (240 mg daily), placebo‐washout, and metoprolol (300 mg daily). Changes induced by stress tests for systolic and diastolic blood pressure, heart rate (HR), and forearm blood flow (FBF) were of the same order on both β‐blockers. Rises in HR and FBF were equally reduced by both drugs. Neither handgrip exercise nor mental arithmetic induced significant differences in reaction during selective and nonselective β‐blockade. Clinical Pharmacology and Therapeutics (1983) 34 , 164–169; doi: 10.1038/clpt.1983.147