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Busulfan kinetics
Author(s) -
Ehrsson Hans,
Hassan Moustapha,
Ehrnebo Mats,
Beran Miloslav
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.134
Subject(s) - busulfan , chemistry , kinetics , absorption (acoustics) , urine , pharmacokinetics , lag time , elimination rate constant , chromatography , pharmacology , medicine , transplantation , volume of distribution , materials science , biochemistry , biology , hematopoietic stem cell transplantation , physics , quantum mechanics , biological system , composite material
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration‐time data could be fitted to a zero‐order absorption one‐compartment open model. The elimination rate constant averaged 0.27 ± 0.05 hr −1 (SD). The plasma AUC was linearly related to the dose. The lag time for the start of absorption, the time absorption ends, and the absorption rate constant showed some interindividual variations. About 1% of busulfan is excreted unchanged in urine over 24 hr. Clinical Pharmacology and Therapeutics (1983) 34, 86–89; doi: 10.1038/clpt.1983.134