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Hemodynamic effects of dobutamine in patients with alcoholic cirrhosis
Author(s) -
Mikulic Esteban,
Muñoz Cristina,
Puntoni Lidia E,
Lebrec Didier
Publication year - 1983
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1983.129
Subject(s) - dobutamine , cardiac output , cirrhosis , medicine , hemodynamics , cardiology , blood flow , heart rate , alcoholic liver disease , anesthesia , blood pressure
The effects of dobutamine infusion on cardiac output, hepatic blood flow, and the gradient between wedged and free hepatic venous pressures were studied in 14 patients with alcoholic cirrhosis. Cardiac output rose from 5.8 ± 1.2 l/min (mean ± SD) to 7.1 ±7.5 l/min. Hepatic blood flow and the gradient between wedged and free hepatic venous pressures did not change significantly during the dobutamine infusion (1.360 ± 0.510 l/min to 1.446 ± 0.502 l/min and 17.7 ± 4.9 mm H g to 17.9 ± 3.7 mm Hg). We conclude that in alcoholic cirrhotic patients, dobutamine increased cardiac output as a result of increased heart rate and that there were no significant changes in percentage of cardiac output distributed to the liver. Clinical Pharmacology and Therapeutics (1983) 34, 56–59; doi: 10.1038/clpt.1983.129